Effects of LH-RH agonist or LH-RH immunoneutralization on pituitary and ovarian LH-RH receptors in female rats
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چکیده
منابع مشابه
Down-regulation of pituitary receptors for luteinizing hormone-releasing hormone (LH-RH) in rats by LH-RH antagonist Cetrorelix.
Antagonists of luteinizing hormone-releasing hormone (LH-RH), unlike the LH-RH agonists, suppress gonadotropins and sex steroid secretion immediately after administration, without initial stimulatory effects. [Ac-D-Nal(2)1,D-Ph(4Cl)2,D-Pal(3)3,D-Cit6,D-Ala10]LH-R H (SB-75; Cetrorelix) is a modern, potent antagonistic analog of LH-RH. In this study, the binding characteristics of receptors for L...
متن کاملLuteinizing hormone-releasing hormone (LH-RH) antagonist Cetrorelix down-regulates the mRNA expression of pituitary receptors for LH-RH by counteracting the stimulatory effect of endogenous LH-RH.
The mechanisms through which LH-RH antagonists suppress gonadotroph functions and LH-RH receptor (LH-RH-R) production are incompletely understood. To elucidate these mechanisms, we investigated the effects of Cetrorelix on the mRNA expression of pituitary LH-RH-R and luteinizing hormone (LH) secretion in three experimental systems with different pituitary LH-RH environments. Ovariectomy induced...
متن کاملThe effect of LH-RH administration on LH release in the female rabbit.
Intracarotid infusion of LH-RH to female rabbits stimulated a significant increase in plasma LH concentration in the jugular vein. This response varied with the reproductive state of the animal, with a greater release occurring in oestrous (spontaneous or oestrogen-induced) and non-receptive does than in pseudopregnant or ovariectomized animals. If ovariectomized rabbits were pretreated with oe...
متن کاملSuppression of serum LH-RH and LH in rats by an inhibitor of norepinephrine synthesis.
Monoamine synthesis inhibitors have been used extensively to unravel the role of neurotransmitters in the hypothalamic regulation of pituitary LH release (Coppola, Leonardi & Lippmann, 1966; Kordon & Glowinski, 1972; Kalra, P.S. & McCann, 1973). Inhibition of tyrosine hydroxylase by \g=a\-methyl-paratyrosine(Corrodi & Hansen, 1966) or dopamine-\g=b\-hydroxylaseby sodium diethyldithiocarbamate (...
متن کاملEffect of LH-RH on the release of sulfated lutropin: a potential in vitro bioassay for LH-RH.
Sheep pituitary cells prelabelled with radioactive [35S] sulfate (35SO4(2-)) were incubated with different concentrations of LH-RH and the release of LH (lutropin) into the medium was monitored in terms of immunoprecipitable [35S] sulfated LH radioactivity and estimation of LH in the same sample by radioimmunoassay. A dose dependent response was obtained with a maximum of a 16 fold increase in ...
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ژورنال
عنوان ژورنال: Reproduction
سال: 1983
ISSN: 1470-1626,1741-7899
DOI: 10.1530/jrf.0.0690245